We’re building a future where silk heals

We are a next-generation biotechnology startup combining the extraordinary properties of silk with deep expertise in blood cell production. Our mission? To recreate bone marrow from the ground up.

Our technology

Accurate.
Predictive.
Scalable.

We offer advanced three-dimensional bone marrow models that closely mimic in vitro the intricate bone marrow niches. Our models have been extensively validated and are the result of more than 15 years of deep experience in the field.

Our platform transforms hematological and oncological drug development from the ground up—delivering precise disease modeling and intelligent candidate selection that reduces attrition and accelerates translational success. This accurate, predictive, and scalable approach is already trusted by leading pharmaceutical innovators to advance their research and strengthen their drug pipelines.

About Us

Made in Europe

We are developing a functionalized bioink that mimics the softness and biocompatibility of human bone marrow with 3D bio-printing to recreate programmable human bone marrow environments where blood cells are produced.

€8m

European Innovation Council Grants

“Science must be visionary, not reactive. At Silk4B, we combine deep experience with nature-inspired design to build sustainable biomedical solutions. Our 3D bone marrow model replaces outdated systems —transforming how we understand and replicate hematopoiesis in the lab.”

Alessandra Balduini picture

Alessandra Balduini

Chief Executive Officer